2022 Dec 17;12(12):1283. doi: 10.3390/metabo12121283. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. Collagen benefits for skin and hair.*. Cureus. For most people, taking collagen peptide supplements should not have any major effects or health consequences, and topical collagen peptide products in particular are unlikely to pose a risk. The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis. Dressler P, Gehring D, Zdzieblik D, Oesser S, Gollhofer A, Knig D. Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability. However, the likelihood of a headache due to collagen may be minimal in comparison to the many benefits of collagen., When looking for a collagen supplement, check the ingredient label and see what the absorption rate is. Nutrients 2021;13(12):4372. Sugihara F, Inoue N, Venkateswarathirukumara S. Ingestion of bioactive collagen hydrolysates enhanced pressure ulcer healing in a randomized double-blind placebo-controlled clinical study. 8600 Rockville Pike SkinnyFit Super Youth Side Effects View abstract. While we have no reports of ProT Gold users experiencing headaches or migraines after using our collagen products, preliminary research into the topic suggests that there may be a correlation between some collagen supplements and headaches., Whether collagen can cause headaches or not often is dependent on the person taking the supplement, the dosage, the type of collagen, and the supplement quality itself., If you suspect that your supplemental collagen can cause headaches or migraines, then exploring why you have this reaction and how to prevent it will be the first place to start., Before we get into whether collagen can cause headaches, lets look at the overall safety of collagen supplements in general., If youre asking the question: can collagen cause headaches? You are probably also interested in other possible side effects of collagen, and if collagen is a safe supplement to take., Its hard to answer whether collagen can cause headaches and if the supplement itself is safe, simply because the FDA does not regulate most supplements., Since there is such limited regulation of supplements on the market, this leads to immense skepticism regarding how safe they really are and what side effects they cause., The lack of regulation when it comes to supplements versus drugs means that not all supplement companies necessarily have to prove their claims., So, if they are simply trying to sell a product to the consumer, they do not have to have evidence to support whether or not the collagen supplement they are providing actually will benefit the consumer, or whether their supplemental collagen can cause headaches or other issues., Still, the FDA does recognize ingestible collagen as Generally Recognized As Safe (GRAS)., There have been specific collagen supplements that have been recalled by the FDA for safety reasons, which is why it is important to buy from a reputable brand., For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a nutritional label, not a supplement label., Because of this, ProT Gold is also trusted by over 3,000 medical facilities and used widely for medical nutrition therapy., Something that should be recognized about collagen as a supplement is that it is natural. Schwartz SR, Park J. Ingestion of BioCell Collagen, a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs. Can Undergoing the hydrolyzation process makes collagen easier for the body to absorb. Mayo Clinic Q and A: Collagen and biotin supplements Unfortunately, our bodies produce about 1% less collagen 1 with each passing year, and we're Appl Physiol Nutr Metab. 2023 Jan;13(1):e2820. Both effects persisted after 12 weeks. A randomized double blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II in adults with osteoarthritis. Other supplements like magnesium may also have a similar effect to too much calcium., Most collagen users benefit from the additional boost in calcium absorption as it can improve bone density among other things. 5. Certain foods contain nutrients that are necessary for collagen production. Federal government websites often end in .gov or .mil. 2020;12(3):618.View abstract. eCollection 2022. Human skin explants were used to study extracellular matrix components in the presence of collagen peptides ex vivo. Medical News Today only shows you brands and products that we stand behind. So as you see, collagen can cause headaches and other issues in some people. 2019;11(1). It is responsible for several biological functions, one of which is to provide structural support in connective tissue, muscle, and skin. Collagen side effects may, for instance, be a result of excessive collagen intake. Epub 2013 Dec 24. Zdzieblik D, Jendricke P, Oesser S, Gollhofer A, Knig D. The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. It is made up of amino acids which build our skin, connective tissue, organs, and bones and plays a role in forming the fibroblasts (cell clusters) which allow new cells to grow and replace dead ones. Side effects vary depending on which type of collagen supplement you take, but they are generally minor overall. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. For example, one small study had women take either calcium or calcium and collagen supplements for 1 year. pii: E97. Bethesda, MD 20894, Web Policies Insulin is an example of a peptide drug, which is composed of 51 amino acids. Similar to vegan options, a person may want to look for a collagen supplement that specifically aims to support the keto diet. 2012;60(16):4096-4101. Int J Environ Res Public Health 2021;18(9):4837. Effects of collagen peptides on recovery following eccentric exercise in resistance-trained males-A pilot study. This means that the manufacturer has broken the collagen in the supplements down into peptides, making it easier for the body to absorb and use. These include: Collagen peptide supplements can offer a range of benefits from improved skin health to a reduction in joint pain and stronger hair and nails. J Med Food. What Are the Side Effects of Collagen Supplements? An official website of the United States government. It's possible to be sensitive or allergic to certain collagen Praet SFE, Purdam CR, Welvaert M, et al. National Library of Medicine Collagen peptide supplements can however lead to dermatological, digestive side, and other side effects, particularly in products with poorly sourced ingredients. Mar Drugs. Moskowitz RW. Cardiovascular health: Insomnia linked to greater risk of heart attack. 2005 - 2023 WebMD LLC. Oxid Med Cell Longev. 2017 Nov 2;14(6):706-714. doi: 10.1080/19390211.2017.1310781. View abstract. WebGlutamate is implicated in cortical spreading depression, trigeminovascular activation, and central sensitization. Drugs. J Musculoskelet Neuronal Interact. 2020;46(1):156-163. Others may experience side effects causing issues with the skin or digestive system, among other problems, but the likelihood of this is based largely on the quality of your chosen collagen peptides product. Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. Collagen National Library of Medicine Adv Skin Wound Care. Before Most collagen supplements are not vegan or vegetarian friendly. Collagen has become so popular in recent years because of its incredible benefits. Because the law does not require cosmetics to be approved by the FDA (Food and Drug Administration), topical skin care products containing collagen peptides are not regulated. There are some reports that collagen supplements may cause other digestive side effects, such as heartburn and feelings of fullness ( 21 ). pii: E1356. 2022 Sep 2;23(1):113. doi: 10.1186/s10194-022-01478-w. Medicine (Baltimore). 2004;26(3-4):105-11. The information on our website is intended for educational purposes only. Int J Sport Nutr Exerc Metab. View abstract. Insulin is an example of a peptide drug, which is composed of 51 amino acids. J Sports Sci Med. HHS Vulnerability Disclosure. View abstract. Dietary supplements do not improve bone morphology or mechanical properties in young female C57BL/6 mice. Additionally, collagen contains various animal proteins, which can cause allergic reactions in some people. Kouguchi T, Ohmori T, Shimizu M, et al. Zehra A, Burns J, Liu CK, et al. doi: 10.1002/brb3.2820. 2022 Jan 28;23(3):1529. doi: 10.3390/ijms23031529. View abstract. Results: The collagen density in the dermis significantly increased and the fragmentation of the dermal collagen network significantly decreased already after 4 weeks of supplementation. Jacob Y, Anderton RS, Cochrane Wilkie JL, Rogalski B, Laws SM, Jones A, Spiteri T, Hince D, Hart NH. COLLAGEN PEPTIDES - Uses, Side Effects, and More Unable to load your collection due to an error, Unable to load your delegates due to an error. View abstract. Clark KL, Sebastianelli W, Flechsenhar KR, et al. Nutrients 2021;13(7):2454. We avoid using tertiary references. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. If you take more collagen than your body can digest, it will cause problems adapting the body to new levels of energy. If you experience any adverse reactions after taking collagen, stop taking it and speak to your View abstract. Many believe that collagen supplements can help reduce the effects of aging, such as by adding moisture to the skin, reducing wrinkles, and improving elasticity. 2009;73(2):422-4. There are also claims that collagen may help prevent skin conditions such as acne. Lis DM, Baar K. Effects of Different Vitamin C-Enriched Collagen Derivatives on Collagen Synthesis. What are L-tryptophan supplements? Collagen supplements Something that should be recognized about collagen as a supplement is that it is natural. 2014;27(3):113-9. Also, Collagen Peptides supplements have not been found to cause any significant health risks for the majority of consumers. Hakuta A, Yamaguchi Y, Okawa T, Yamamoto S, Sakai Y, Aihara M. Anti-inflammatory effect of collagen tripeptide in atopic dermatitis. Epub 2022 Dec 1. Updated February 27, 2014. View abstract. Asserin J, Lati E, Shioya T, Prawitt J. Prokopov A, Pavlackov J, Mokrejs P, Gl R. Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation. Manufacturers tend to produce them using the bones and protein of animals. Trc T, Bohmov J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). View abstract. Can Collagen Cause Diarrhea? Lin P, Alexander RA, Liang CH, et al. Taking collagen peptides by mouth might slightly relieve pain and improve joint function in people with. However, it is possible to have too much of a good thing., If calcium is the cause of your collagen-related headache problems, then a simple change in collagen supplement dosage may be in order to reduce the likelihood that your collagen can cause headaches., If you are worried about or already are experiencing headaches from your collagen supplements then it is best to consult a medical professional. sharing sensitive information, make sure youre on a federal Can Collagen Supplements Cause High Cholesterol Topical application and oral supplementation of peptides in the improvement of skin viscoelasticity and density. This Collagenous colitis The researchers found that the women taking the calcium and the collagen had lower levels of a protein responsible for breaking down bones in their blood. Collagen Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. View abstract. J Med Food. Most people can take collagen supplements without 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Subscribe to get special offers, free giveaways, and once-in-a-lifetime deals. There is some evidence to suggest that using collagen supplements may help increase muscle mass. Oral collagen supplements also increase skin elasticity, hydration, and dermal collagen density. Collagen supplements have the potential to cause both headaches and migraines. This site needs JavaScript to work properly. 2021;20(1):188-194. Kim DU, Chung HC, Choi J, Sakai Y, Lee BY. Sports Med Open. 2016 Feb;116(2):353-62. doi: 10.1007/s00421-015-3290-x. Skin Pharmacol Physiol. Then, we recommend you evaluate the supplement itself along with the dosage you have been using., Not all collagen supplements are created equal and whether collagen can cause headaches may have more to do with the type of collagen you use and its bioavailability to you., When looking at the quality of a collagen supplement, first and foremost check to see if the company can back up their claims., If a company is making any kind of result claims regarding collagens ability to help resolve issues (especially medical issues) then they need to have resources, case studies, and other research to back up these claims., Since the FDA does not regulate collagen supplements as closely as they should, a lot of this is left up to the consumer to identify and sift through. 2019 Jan;98(3):e14099. That being said, we want to point out that these side effects are not common. Collagen vs. biotin for the skin and hair, What to know about L-tryptophan supplements, The best collagen supplements: How to choose, a general feeling of heaviness in the stomach. Skin rashes. Aguirre A, Gil-Quintana E, Fenaux M, Erdozain S, Sarria I. J Diet Suppl. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Quantitative assessment of the association between. Collagen View abstract. Collagen is a type of structural protein in the body. Theres currently 80 approved peptide drugs worldwide. The oral supplementation with collagen peptides is efficacious to improve hallmarks of skin aging. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. Also, in many cases, the collagen is hydrolyzed. Your body makes collagen naturally, but you can also consume it through collagen supplements Side Effects of Collagen Peptides on Skin, Digestion, and Chemical additives in collagen peptide supplements, such as anti-caking substances and preservatives are common causes of acne flare-ups in those who notice increased breakouts with collagen use. The source of the collagen itself should also be a consideration, primarily for those that have a fish or shellfish allergy of any kind. Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage. MeSH Biosci Rep. 2018 Dec 14;38(6):BSR20181347. Collagen powder can sometimes have a bad taste but can be blended into a smoothie, while pills have the benefit of being tasteless but are generally large in size. Accessibility The effects of collagen peptides on muscle damage, inflammation and bone turnover following exercise: a randomized, controlled trial. View abstract. Our team thoroughly researches and evaluates the recommendations we make on our site. If you have a history of calcium oxalate kidney stones, exercise caution when incorporating collagen peptides by beginning with no more than about 1 tablespoon per day, and always stay well-hydrated. and transmitted securely. Wauquier F, Boutin-Wittrant L, Bouvret E, Le Faouder J, Roux V, Macian N, Pickering G, Wittrant Y. Nutrients. doi: 10.1042/BSR20181347. Whether or not collagen supplements are effective depends on what a person uses collagen for. It's found in our tendons, ligaments, skin, muscles, bones, and blood vesselsand it plays a vital role in maintaining our overall structural integrity. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Some other known benefits of collagen peptides include: Consuming collagen peptides are good for you insofar as they may offer a variety of health benefits, from improving joint health to improving your skin. However, it might also help promote other areas of health, such as bone, joint, and heart health. Beneficial Effects of Oral Supplementation With Ovoderm on Human Skin Physiology: Two Pilot Studies. 2018 Apr;15(2):361-370. doi: 10.1007/s13311-018-0616-5. View abstract. Bookshelf So as you see, collagen can cause headaches and other issues in some people. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Collagen Peptides However, more research is necessary to prove the effects of collagen in supporting heart health. Oral collagen peptide supplementation significantly increased skin hydration after 8 weeks of intake. Antioxidants for preventing and reducing muscle soreness after exercise. Rheumatoid arthritis, lupus, dermatomyositis and scleroderma are autoimmune, connective tissue diseases known to damage collagen. PMC In some individuals, this can trigger the formation of kidney stones. However, scientists have not fully studied all the alleged benefits. HIGH CHOLESTEROL on Keto Diet (My 4-Year High Fat Diet Results!) Collagen is the protein responsible for skin elasticity. View abstract. Ranchordas MK, Rogerson D, Soltani H, Costello JT. Wunsch, A., & Matuschka, K. (2014). and transmitted securely. View abstract. View abstract. MeSH A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase. The participants skin hydration and elasticity also improved significantly. Sports Med. The participants study took 15 grams (g) of collagen or a placebo pill per day. Collagen formula with Djulis for improvement of skin hydration, brightness, texture, crow's feet, and collagen content: A double-blind, randomized, placebo-controlled trial. Select a condition to view a list of vitamins. 2020;111(3):708-718. Most collagen users do not experience any adverse effects when taking a high-quality collagen supplement at the proper dosage., The source of the collagen is also a huge factor in whether or not collagen can cause headaches and other side effects., For instance, many bone broth based collagen supplements are very high in sodium and potassium, not to mention the collagen in that type of supplement is harder to digest.. Prowting JL, Bemben D, Black CD, Day EA, Campbell JA. ANSWER: Collagen and biotin supplements appear to be getting attention in the media for promoting healthy aging, along with joint and bone health. 2009 Jun;18(6):789-803. doi: 10.1517/13543780902913792. Type 1: This is one of the most abundant types present in the human body and helps support healthy skin. eCollection 2022 Aug. doi: 10.7759/cureus.27666. J Cosmet Dermatol. Unable to load your collection due to an error, Unable to load your delegates due to an error. Possible side effects include: Upset stomach Diarrhea Rashes, or skin reactions Nausea Constipation Heartburn Headache 2015;18(12):1340-8. 2019;11(4). Excessive collagen peptides can lead to a deficit in tryptophan, which causes your serotonin levels to lower. What is the latest research on the form of cancer Jimmy Carter has? Semin Arthritis Rheum. Your Collagen Supplement Causing Headaches Maia Campos PMBG, Melo MO, Siqueira Csar FC. 2023 Copyright Derm Collective. There is some evidence to back these claims up. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. However, its important to ensure you do not have allergies or sensitivities to collagen and that you select a quality product in order to avoid unnecessary side effects. View abstract. Conclusions and Relevance: Preliminary results are promising for the short and long-term use of oral collagen supplements for wound healing and skin aging. Genetic Variants within NOGGIN, COL1A1, COL5A1, and IGF2 are Associated with Musculoskeletal Injuries in Elite Male Australian Football League Players: A Preliminary Study. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Sci Rep. 2018;8(1):11403. To protect collagen stores, doctors recommend you use a broad-spectrum sunscreen with an SPF of 30 or higher every day, refrain from, Topical creams which include retinoic acid or, Despite the well-known risks of exposure to. Collagen supplements can help improve skin health. 2014;39(8):874-80. Whether used as a powder in smoothies or as oral supplements, collagen has all the rage nowadays. sharing sensitive information, make sure youre on a federal Tajti J, Szok D, Nagy-Grocz G, Tuka B, Petrovics-Balog A, Toldi J, Vecsei L. Curr Med Chem. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Collagen supplements may help support skin, hair, and joint health. Protein and Sport: Alternative Sources and Strategies for Bioactive and Sustainable Sports Nutrition. Nutrition is a key factor influencing skin health and consequently its appearance. Can diet help improve depression symptoms? Of those side effects, there has been a recurring theme among many collagen users asking: For instance, our liquid collagen supplement, ProT Gold, is actually recognized as a medical food, which is why it has a, nutritional label, not a supplement label. J Sci Food Agric. Muscle soreness was not significantly different in CP and CON (P = 0.071) but a large effect size was evident at 48 h post-exercise, indicative of lower soreness in the CP group (90.42 45.33 mm vs. CON 125.67 36.50 mm; ES = 2.64). pii: E157. Although they are most popularly used to combat the signs of aging in the skin, collagen peptides can provide a number of other potential benefits as well. FOIA The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). If youre in a state of chronic migraine or get attacks often, I recommend avoiding collagen peptides unless its prescribed by your physician. Lpez-Martnez MI, Miguel M, Garcs-Rimn M. Front Nutr. The best vitamins for skin include vitamins C, D, and E. People can get many of these vitamins from their diet or by taking supplements. 5. Also, as with any supplement, the Food and Drug Administration (FDA) do not evaluate any claims that a company makes on how well their collagen product works. Best overall collagen supplement: Vital Proteins Collagen Peptides. Using a Yes. Please enable it to take advantage of the complete set of features! View abstract. Alcock RD, Shaw GC, Tee N, Welvaert M, Burke LM. There are several potential health benefits that collagen supplements offer. Taking collagen supplements may also help support a healthy cardiovascular system. Zmitek K, Zmitek J, Rogl Butina M, Pogacnik T. Effects of a combination of water-soluble coenzyme Q10 and collagen on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. View abstract. 2018;13(4):438-52. Collagen and biotin may both help promote skin and hair health, but each has different pros and cons. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Can Collagen Its important, in such cases, not to over-consume collagen peptides or take them right before sleeping. Zhu CF, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. A person can also use collagen supplements while following a keto diet plan. There are numerous reasons why you might be taking a collagen supplement. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. 2010;35(6):797-804. As a result, a persons skin begins to lose some of its ability to bounce back into shape, a process that many call elasticity. As this occurs, wrinkles begin to form. Nutrients. Int J Sport Nutr Exerc Metab. government site. Collagen Collagen is a protein that our body already produces, , so when taking it in a supplement form, you are replenishing your collagen stores with animal-based collagen., Beyond the product itself and ingredients, dosage can also impact, how safe it is to use collagen as a daily supplement, Digestive upset such as bloating and nausea, Allergic reactions and general collagen sensitivities, when participants were using the collagen supplement, they did report a lower pain level in their joints but among the most commonly reported side effects was a headache from time to time., However, one common trend we found in our research for this article is that the type of collagen and quality of the supplement itself contributes a lot to the, potential for side effects like headaches, It has been considered that collagen may cause headaches for some users because it can raise your calcium levels. Clipboard, Search History, and several other advanced features are temporarily unavailable. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Peptides Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial. Unauthorized use of these marks is strictly prohibited. Insulin is an example of a peptide drug, which is composed of 51 amino acids. Collagen The site is secure. Careers. As with any supplement, collagen supplements do have some potential side effects, especially when taken in excess. View abstract. View abstract. Maia Campos PMBG, Franco RSB, Kakuda L, Cadioli GF, Costa GMD, Bouvret E. Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. WebCollagen type II (native) is a protein that is part of the cartilage, bone, and other types of connective tissues in animals and humans. Tak YJ, Kim YJ, Lee JG, et al. But these supplements are also touted to support digestion and heart health, prevent bone loss and increase muscle mass. 2022 Sep 16;11(18):2869. doi: 10.3390/foods11182869. WebCollagen peptides are used as a bioactive ingredient in nutricosmetic products and have been shown in preclinical studies to improve skin barrier function, to induce the synthesis of collagen and hyaluronic acid, and to promote fibroblast growth and migration.